XXII

We rate 22nd Century Group, Inc. (XXII) as a Reduce with a composite score of 43.3/100 at a current price of $4.73. The quantitative profile shows weakness across multiple dimensions, suggesting limited upside potential and elevated risk of underperformance relative to peers over the next 12 months.

The rating is primarily driven by strength in momentum (49th percentile) and investment (32th percentile), which together account for the majority of the composite score. Offsetting weakness in value (16th percentile) and quality (21th percentile) tempers our overall conviction. We assign a No Moat rating (14/100), High uncertainty, and Poor capital allocation.

Key items to watch: the path to profitability; valuation compression risk if growth disappoints. Any material change in these dynamics could warrant a reassessment of our rating. The moat trend is stable, which suggests the competitive landscape is stable for now.

22nd Century Group, Inc. holds a top-quartile position (#0 of 50) within the Manufacturing sector, based on our composite quantitative scoring across quality, value, momentum, and stability factors. The composite score of 43.3/100 places it at rank #3076 in our full 7,333-stock universe. At $6M in market capitalization, 22nd Century Group, Inc. is a small-cap player in the Manufacturing space, which limits certain scale advantages but may allow for more agile strategic execution.

Revenue contraction of -50% combined with momentum at the 49th percentile paints a cautious picture of the near-term business outlook. The market appears to be pricing in continued challenges, and a catalyst for reversal is not clearly visible from current data.

The margin cascade tells an important story: gross margins of 39% (-3.3pp vs sector) narrow to operating margins of -63% (-64.5pp vs sector) and net margins of -20.6%, yielding a gross-to-net conversion rate of -53%. The significant margin erosion from gross to net suggests elevated operating expenses, high interest costs, or other structural drags that warrant monitoring.

At a current price of $4.73, 22nd Century Group, Inc. is trading at a premium to fundamental value. Our value factor score of 16/100 reflects a composite assessment across multiple valuation metrics including price-to-earnings, price-to-book, EV/EBITDA, and price-to-sales ratios relative to both sector peers and the broader market. The premium valuation implies the market is pricing in significant future growth or quality improvements that are not yet fully reflected in current fundamentals.

The stock currently trades at a P/E of 3.1x (a 86% discount to the sector median of 22.3x), P/B of 0.2x, P/S of 0.1x. The below-sector P/E suggests possible undervaluation or the market pricing in near-term headwinds.

We assign a High uncertainty rating to 22nd Century Group, Inc.. Key risk factors include current negative profitability (net margin -20.6%), below-average price stability (26th percentile), weak quality scores (21th percentile). The wide range of potential outcomes widens our fair value estimate and increases the possibility of permanent capital impairment. Investors considering this name should size positions accordingly and demand a meaningful margin of safety before initiating.

Specific risk factors that inform our assessment include: current negative profitability (net margin -20.6%); below-average price stability (26th percentile); weak quality scores (21th percentile); low beta of -0.03 — while defensive, this may indicate limited upside participation in bull markets. Each of these factors independently widens the distribution of potential outcomes, and in combination they create a risk profile that demands careful position sizing. The stability factor at the 26th percentile and quality factor at the 21th percentile provide a quantitative summary of the overall risk landscape.

We identify limited risk mitigants at this time, which contributes to our high uncertainty assessment. Investors should monitor for improvement in balance sheet metrics, margin stability, and business predictability that could warrant a downgrade in our risk assessment over time.

We rate 22nd Century Group, Inc.'s capital allocation as Poor. Key concerns include low returns on equity (-32.7%), negative profitability, weak asset returns (ROA -18.6%). Exemplary capital allocators generate ROE above 20% and maintain conservative leverage — 22nd Century Group, Inc. significantly underperforms these benchmarks, raising questions about management's ability to create shareholder value.

Investors should scrutinize management's reinvestment decisions and balance sheet trajectory before committing capital. Poor capital allocation often compounds over time: overlevered balance sheets limit strategic flexibility, while low returns on capital destroy shareholder value. We would need to see sustained improvement in profitability metrics and balance sheet discipline before considering an upgrade.

In summary, 22nd Century Group, Inc. receives a Reduce rating with a composite score of 43.3/100 (rank #3076 of 7,333). Our quantitative framework assigns a No Moat (14/100, trend: stable), High uncertainty, and Poor capital allocation. The average factor score across quality, value, momentum, stability, and investment is 29/100.

Our analysis does not support a constructive view on 22nd Century Group, Inc. at this time. The combination of limited competitive advantages, high uncertainty, and poor capital allocation suggests unfavorable risk-reward at current levels. We recommend investors avoid new positions and existing holders consider reducing exposure.