BFRG

Company Overview — What Does BullFrog AI Holdings, Inc. Do?

Most new therapeutics will fail at some point in preclinical or clinical development. This is the primary driver of the high cost of developing new therapeutics. A major part of the difficulty in developing new therapeutics is efficient integration of complex and highly dimensional data generated at each stage of development to de-risk subsequent stages of the development process. Artificial Intelligence and Machine Learning (AI/ML) has emerged as a digital solution to help address this problem. We use artificial intelligence and machine learning to advance medicines for both internal and external projects. We are committed to increasing the probability of success and decreasing the time and cost involved in developing therapeutics. Most current AI/ML platforms still fall short in their ability to synthesize disparate, high-dimensional data for actionable insight. Our platform technology, named, bfLEAP™, is an analytical AI/ML platform derived from technology developed at The Johns Hopkins University Applied Physics Laboratory (JHU-APL), which is able to surmount the challenges of scalability and flexibility currently hindering researchers and clinicians by providing a more precise(1), multi-dimensional understanding of their data. We are deploying bfLEAP™ for use at several critical stages of development for internal programs and through strategic partnerships and collaborations with the intention of streamlining data analytics in therapeutics development, decreasing the overall development costs by decreasing failure rates for new therapeutics, and impacting the lives of countless patients that may otherwise not receive the therapies they need. The bfLEAP™ platform utilizes both supervised and unsupervised machine learning – as such, it is able to reveal real/meaningful connections in the data without the need for a prior hypothesis. Supervised machine learning uses labeled input and output data, while an unsupervised learning algorithm does not. In supervised learning, the algorithm “learns” from the training dataset by iteratively making predictions on the data and adjusting for the correct answer. Unsupervised learning, also known as unsupervised machine learning, uses machine learning algorithms to analyze and cluster unlabeled datasets. These algorithms discover hidden patterns or data groupings without the need for human intervention. Algorithms used in the bfLEAP™ platform are designed to handle highly imbalanced data sets to successfully identify combinations of factors that are associated with outcomes of interest. Together with our strategic partners and collaborators, our primary goal is to improve the odds of success at any stage of pre-clinical and clinical therapeutics development. Our primary business model is improving the success and efficiency of drug development which is accomplished either through acquisition of drugs or partnerships and collaborations with companies that are developing drugs. We hope to accomplish this through strategic acquisitions of current clinical stage and failed drugs for in-house development, or through strategic partnerships with biopharmaceutical industry companies. We are able to pursue our drug asset enhancement business by leveraging a powerful and proven AI/ML platform (trade name: bfLEAP™) initially derived from technology developed at JHU-APL. We believe the bfLEAP™ analytics platform is a potentially disruptive tool for analysis of pre-clinical and/or clinical data sets, such as the robust pre-clinical and clinical trial data sets being generated in translational R&D and clinical trial settings. In November 2021, we amended the agreement with JHU-APL to include additional advanced AI technology. On July 8, 2022, the Company entered into an exclusive, world-wide, royalty-bearing license from JHU-APL for the additional technology developed to enhance the bfLEAP™ platform. The July 8, 2022 JHU-APL license provides the Company with new intellectual property and also encompasses most of the intellectual property from the February 2018 license. We believe bfLEAP™ will inform/enable decision making throughout the development cycle: . 1. Discovery Phase – Analyze and categorize discovery phase data to better define highest-value leads from groups of candidates, for advancement to preclinical phase of development. Integrate data from high-throughput screening, pharmacodynamics assays, pharmacokinetics assays, and other key data sets to create the most accurate profile of a pool of therapeutic candidates. There is often a high degree of similarity among closely related therapeutics in a candidate pool – bfLEAP™ is able to harmonize disparate data streams for a more nuanced understanding of each candidate’s characteristics/potency. . 2. Pre-Clinical Data - Large-scale/multivariate analysis of pre-clinical and/or early-stage clinical data sets. In these settings, bfLEAP could be used to find novel drug targets, elucidate mechanism of action (MOA), predict potential off-target effects/side effects, uncover specific genetic/phenotypic background(s) with highest correlation to therapeutic response, etc. These insights from bfLEAP™ analysis can be used to inform decision making/study design at the subsequent step(s) of therapeutic/diagnostic development, including first-inhuman/Phase I RCTs. . 3. Clinical Development - Advanced/multivariate analysis of PhI and/or PhII clinical trials data, to find niche populations of highly responsive patients and/or inform patient selection for later-stage CT(s). This can be used to decrease overall study risk for larger clinical trials - including Phase II trials, and any Phase III Registration Clinical Trials. The bfLEAP™ platform analysis can also be used to more precisely understand complex correlations between therapeutic treatment and adverse events, side effects, and other undesirable responses which could jeopardize clinical trial success. Our platform is agnostic to the disease indication or treatment modality and therefore we believe that it is of value in the development of biologics or small molecules. The process for our drug asset enhancement program is to: . acquire the rights to a drug from a biopharmaceutical industry company or academia; . use the proprietary bfLEAP™ AI/ML platform to determine a multi-factorial profile for a patient that would best respond to the drug; . rapidly conduct a clinical trial to validate the drug’s use for the defined “high-responder” population; and . divest/sell the rescued drug asset with the new information back to a large player in the pharma industry, following positive results of the clinical trial. As part of our strategy, we will continue evolving our intellectual property, analytical platform and technologies, build a large portfolio of drug candidates, and implement a model that reduces risk and increases the frequency of cash flow from rescued drugs. This strategy will include strategic partnerships, collaborations, and relationships along the entire drug development value chain, as well as acquisitions of the rights to developing failed drugs and possibly the underlying companies. To date, we have not conducted clinical trials on any pharmaceutical drugs and our platform has not been used to identify a drug candidate that has received regulatory approval for commercialization. However, wecurrently have a strategic relationship with a leading rare disease non-profit organization for AI/ML analysis of late stage clinical data. We have also positioned the Company to acquire the rights to a series of preclinical and early clinical drug assets from universities, as well as a strategic collaboration with a world renowned research institution to create a HSV1 viral therapeutic platform to engineer immunotherapies for a variety of diseases. In addition, we have signed exclusive world-wide license agreements with Johns Hopkins University for a cancer drug that targets glioblastoma (brain cancer), pancreatic cancer, and other cancers. We have also signed an exclusive worldwide license with George Washington University for another cancer drug that targets hepatoceullar carcinoma (liver cancer), and other liver diseases. Our platform was originally developed by the JHU-APL. JHU-APL uses the same technology for applications related to national defense. Over several years, the software and algorithms have been used to identify relationship, patterns, and anomalies, and make predictions that otherwise may not be found. These discoveries and insights provide an advantage when predicting a target of interest, regardless of industry or sector. We have applied the technology to various clinical data sets and have identified novel relationships that may provide new intellectual property, new drug targets, and other valuable information that may help with patient stratification for a clinical trial thereby improving the odds for success. The platform has not yet aided in the development of a drug that has reached commercialization. However, we own one drug candidate that has completed a phase 1 trial and a second candidate that is in the preclinical stages . Our aim is to use our technology on current and future available data to help us better determine the optimal path for development While we have not generated significant revenues from our AI/ML operations, we anticipate generating revenue in the future from the following three sources: Contract Services Our fee for service partnership offering model is designed for biopharmaceutical companies, as well as other organizations, of all sizes that have challenges analyzing data throughout the drug development process. We provide the customer with an analysis of large complex data sets using our proprietary Artificial Intelligence / Machine Learning platform called bfLEAP™. This platform is designed to predict targets of interest, patterns, relationships, and anomalies. Our service model involves a cash fee plus the potential for rights to new intellectual property generated from the analysis, which can be performed at the discovery, preclinical, or clinical stages of drug development. Collaborative Arrangements We plan to enter into collaborative arrangements with biotechnology and pharmaceutical companies who have drugs that are in development or have failed late Phase 2 or Phase 3 trials. The collaborations may also be at the discovery or preclinical stages of drug development. Our revenue will be a combination of fee for service cash payments and success fees based on achieving certain milestones as determined by each specific arrangement. There may also be fees or legal rights associated with the development of new intellectual property. Acquisition of Rights to Certain Drugs We may acquire the rights to drugs that have failed late Phase 2 or Phase 3 trials and generate revenues by using our platform to accurately determine the profile of patients that would respond to the drugs, conduct a clinical trial to test our findings either independently or with a clinical partner, and finally sell the drug back to pharmaceutical companies. We have and may continue acquiring the rights to drugs that have not yet failed any trials. We will use our technology to improve the chances for success, conduct a trial, and divest the asset. When divesting assets, the transaction may involve a combination of upfront payments, milestone payments based on clinical success, and royalties on sales of the product. (1) In an August 2021 publication in DeepAI.org (https://deepai.org/publication/random-subspace-mixture-models-for-interpretable-anomaly-detection), the algorithms used in bfLEAP were compared to 10 of the most popular clustering algorithms in the world using 12 data sets. The end result showed that the algorithms used in bfLEAP had the highest average score when measuring speed and accuracy of prediction. The bfLEAP platform currently has more advanced versions of these algorithms and is applying them in multiple data analytics projects. Bullfrog AI Holdings, Inc. was incorporated in the State of Nevada on February 6, 2020. Bullfrog AI Holdings, Inc. is the parent company of Bullfrog AI, Inc. and Bullfrog AI Management, LLC. which were incorporated in Delaware and Maryland, in 2017 and 2021, respectively. All of our operations are currently conducted through BullFrog AI Holdings, Inc. The Company’s principal business address is 325 Ellington Blvd, Unit 317, Gaithersburg, MD. BullFrog AI Holdings, Inc. (BFRG) is classified as a micro-cap stock in the Healthcare sector, specifically within the Pharmaceutical Products industry. The company is led by CEO Vininder Singh. With a market capitalization of $21M, BFRG is one of the notable companies in the Healthcare sector.

BullFrog AI Holdings, Inc. (BFRG) Stock Rating — Reduce (April 2026)

As of April 2026, BullFrog AI Holdings, Inc. receives a Reduce rating with a composite score of 19.8/100 and 2 out of 5 stars from the Blank Capital Research quantitative model.BFRG ranks #3,619 out of 4,446 stocks in our coverage universe. Within the Healthcare sector, BullFrog AI Holdings, Inc. ranks #583 of 838 stocks, placing it in the lower half of its Healthcare peers. The rating is generated by a multi-factor model that weighs quality (30%), momentum (25%), value (15%), investment (10%), stability (10%), and short interest (10%).

BFRG Stock Price and 52-Week Range

BullFrog AI Holdings, Inc. (BFRG) currently trades at $0.90. The stock lost $0.14 (13.5%) in the most recent trading session. The 52-week high for BFRG is $2.20, which means the stock is currently trading -59.1% from its annual peak. The 52-week low is $0.43, putting the stock 111.7% above its annual trough. Recent trading volume was 3.4M shares, reflecting moderate market activity.

Is BFRG Overvalued or Undervalued? — Valuation Analysis

BullFrog AI Holdings, Inc. (BFRG) carries a value factor score of 16/100 in the Blank Capital model, signaling premium valuation that prices in significant future growth. The price-to-book ratio stands at 9.93x, versus the sector average of 2.75x. The price-to-sales ratio is 436.26x, compared to 1.66x for the average Healthcare stock.

At current multiples, BullFrog AI Holdings, Inc. trades at a premium to most Healthcare peers. This elevated valuation may be justified if the company can sustain above-average growth rates and profitability, but it also creates downside risk if earnings disappoint expectations.

BullFrog AI Holdings, Inc. Profitability — ROE, Margins, and Quality Score

BullFrog AI Holdings, Inc. (BFRG) earns a quality factor score of 12/100, signaling below-average profitability metrics relative to the broader market. The return on equity (ROE) is -317.4%, compared to the Healthcare sector average of -43.5%, which is below typical expectations for high-quality companies. Return on assets (ROA) comes in at -241.5% versus the sector average of -33.1%.

On a margin basis, BullFrog AI Holdings, Inc. reports gross margins of 19.6%, compared to 71.5% for the sector. The operating margin is -7315.9% (sector: -66.1%). Net profit margin stands at -7225.6%, versus -58.7% for the average Healthcare stock. Profitability is below benchmark levels, which may reflect industry headwinds, elevated reinvestment, or structural challenges.

BFRG Debt, Balance Sheet, and Financial Health

BullFrog AI Holdings, Inc. has a debt-to-equity ratio of 31.0%, compared to the Healthcare sector average of 32.0%. The low leverage indicates a conservative balance sheet with significant financial flexibility. The current ratio is 3.85x, indicating strong short-term liquidity. Total debt on the balance sheet is $55,606. Cash and equivalents stand at $2M.

BFRG has a beta of 2.27, meaning it is more volatile than the broader market — a $10,000 investment in BFRG would be expected to move 127.0% more than the S&P 500 on any given day. The stability factor score for BullFrog AI Holdings, Inc. is 9/100, suggesting elevated price swings that may be unsuitable for conservative portfolios.

BullFrog AI Holdings, Inc. Revenue and Earnings History — Quarterly Trend

In TTM 2026, BullFrog AI Holdings, Inc. reported revenue of $48,627 and earnings per share (EPS) of $-0.63. Net income for the quarter was $-7M. Gross margin was 19.6%. Operating income came in at $-7M.

In FY 2025, BullFrog AI Holdings, Inc. reported revenue of $21,892 and earnings per share (EPS) of $-0.63. Net income for the quarter was $-6M. Operating income came in at $-7M.

In Q3 2025, BullFrog AI Holdings, Inc. reported revenue of $15,370 and earnings per share (EPS) of $-0.15. Net income for the quarter was $-2M. Operating income came in at $-2M.

In Q2 2025, BullFrog AI Holdings, Inc. reported revenue of $33,257 and earnings per share (EPS) of $-0.15. Net income for the quarter was $-1M. Gross margin was 19.6%. Operating income came in at $-1M.

Over the past 8 quarters, BullFrog AI Holdings, Inc. has demonstrated a growth trajectory, with revenue expanding from $0 to $48,627. Investors analyzing BFRG stock should weigh these quarterly trends alongside the valuation and quality metrics discussed above.

BFRG Dividend Yield and Income Analysis

BullFrog AI Holdings, Inc. (BFRG) does not currently pay a dividend. This is common among smaller companies in the Pharmaceutical Products industry that prefer to reinvest cash flows into business expansion rather than returning capital to shareholders. Income-focused investors looking for Healthcare dividend stocks may want to explore other Healthcare stocks or use the stock screener to filter by dividend yield.

BFRG Momentum and Technical Analysis Profile

BullFrog AI Holdings, Inc. (BFRG) has a momentum factor score of 27/100, signaling weak relative price performance. Stocks with low momentum scores have historically tended to continue underperforming in the near term. The investment factor score is 25/100, which measures capital allocation efficiency and asset growth patterns. The short interest score of 37/100 signals elevated short interest, which can indicate bearish sentiment among institutional investors.

BFRG vs Competitors — Healthcare Sector Ranking and Peer Comparison

Within the Healthcare sector, BullFrog AI Holdings, Inc. (BFRG) ranks #583 out of 838 stocks based on the Blank Capital composite score. This places BFRG in the lower half of all Healthcare stocks in our coverage universe. Key competitors and sector peers include ASTRAZENECA PLC (AZN) with a score of 61.4/100, Sol-Gel Technologies Ltd. (SLGL) with a score of 56.6/100, VIEMED HEALTHCARE, INC. (VMD) with a score of 53.4/100, Innoviva, Inc. (INVA) with a score of 52.7/100, and JOHNSON & JOHNSON (JNJ) with a score of 51.7/100.

Comparing BFRG against the S&P 500 benchmark is also instructive for understanding relative performance. Investors can view the full BFRG vs S&P 500 (SPY) comparison to assess how BullFrog AI Holdings, Inc. stacks up against the broader market across all factor dimensions.

BFRG Next Earnings Date

No upcoming earnings date has been announced for BullFrog AI Holdings, Inc. (BFRG) at this time. Check the earnings calendar for the latest scheduling updates across all stocks in our coverage universe.

Should You Buy BFRG? — Investment Thesis Summary

The quantitative profile for BullFrog AI Holdings, Inc. suggests caution. The quality score of 12/100 flags below-average profitability. The value score of 16/100 indicates premium valuation. Momentum is weak at 27/100, a headwind for near-term performance. High volatility (stability score 9/100) increases portfolio risk.

In summary, BullFrog AI Holdings, Inc. (BFRG) earns a Reduce rating with a composite score of 19.8/100 as of April 2026. The rating is derived from the Blank Capital Research methodology, which combines six factor dimensions into a single quantitative ranking. Investors should consider these quantitative signals alongside their own fundamental research, risk tolerance, and investment time horizon before making buy or sell decisions on BFRG stock.

Related Resources for BFRG Investors

Explore more research and tools: BFRG vs S&P 500 comparison, top Healthcare stocks, stock screener, our methodology, quality factor explained, value factor explained, momentum factor explained. Compare BFRG head-to-head with peers: BFRG vs AZN, BFRG vs SLGL, BFRG vs VMD.