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Verdict
Quantitative factor alignment verified for current market regime.
Quant Score
Rank
#1258
Positioning
Market Dominance
Manufacturing
Pharmaceutical Products
$3.6B
Stephen R. Davis
ACADIA Pharmaceuticals Inc. focuses on the development and commercialization of small molecule drugs that address unmet medical needs in central nervous system disorders. The company offers NUPLAZID (pimavanserin) for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.
Headcount
510
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X-AXIS: EV/EBITDA (LOWER = CHEAPER) | Y-AXIS: ROE (HIGHER = ELITE) | RED CIRCLE = ACAD ANALYSIS TARGET
| Stock | Rating | Score▼ | Quality | Value | Momentum | P/E | EV/EBITDA | ROE | ROA | Gross Mgn | Op Mgn | Net Mgn | Rev Growth | Div Yield | D/E | Mkt Cap | AUDIT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
$UL UNILEVER PLC | 78 | 96 | 98 | 59 | - | - | 28.5% | 8.0% | 100.0% | 100.0% | 10.4% | -4.6% | 3.3% | 0.0x | $141.8B | VS | |
$ASML ASML HOLDING NV | 77 | 89 | 86 | 83 | - | - | 46.1% | 16.6% | 51.3% | 31.9% | 26.8% | -4.0% | 1.0% | 25.0x | $272.1B | VS | |
$ESLT ELBIT SYSTEMS LTD | 76 | 81 | 87 | 85 | - | - | 10.3% | 3.1% | 24.1% | 7.2% | 4.7% | 14.3% | 0.8% | 25.0x | $11.4B | VS | |
$MT ArcelorMittal | 75 | 71 | 98 | 85 | - | - | 2.2% | 1.5% | 9.3% | 5.3% | 2.2% | -8.5% | 2.2% | 16.0x | $18.9B | VS | |
$AMAT APPLIED MATERIALS INC /DE | 75 | 85 | 87 | 84 | 20.9x | 13.6x | 35.5% | 19.8% | 48.7% | 29.2% | 24.7% | 4.4% | 0.8% | 32.0x | $181.9B | VS | |
$SIMO Silicon Motion Technology CORP | 75 | 84 | 86 | 85 | - | - | 11.8% | 8.8% | 45.9% | 11.3% | 11.1% | 25.7% | 3.7% | 0.0x | $1.8B | VS | |
$CODA Coda Octopus Group, Inc. | 74 | 83 | 90 | 79 | 16.3x | 11.9x | 7.6% | 7.0% | 66.5% | 17.1% | 15.6% | 39.0% | 0.0% | 0.0x | $115M | VS | |
$GSK GSK plc | 74 | 84 | 90 | 70 | - | - | 22.6% | 4.9% | 71.2% | 12.8% | 9.4% | 1.7% | 5.9% | 124.0x | $72.1B | VS | |
$EFXT Enerflex Ltd. | 74 | 80 | 91 | 83 | - | - | 3.0% | 1.1% | 20.9% | 7.3% | 1.3% | 3.0% | 0.9% | 67.0x | $1.2B | VS | |
$BUD Anheuser-Busch InBev SA/NV | 74 | 84 | 97 | 63 | - | - | 8.2% | 3.5% | 55.3% | 25.9% | 12.4% | 0.7% | 1.7% | 0.0x | $87.0B | VS | |
$ACAD ACADIA PHARMACEUTICALS INC | 55 | 71 | 64 | 55 | 27.0x | 34.1x | 16.4% | 11.3% | 92.1% | 11.4% | 14.2% | 15.2% | 0.0% | 45.0x | $3.6B | ||
| SECTOR BENCH | - | - | - | - | - | 22.3x | 11.5x | -2.5% | -0.1% | 42.5% | 1.3% | -0.2% | 5.9% | 0.0% | 0.2x | - | REF |
ACADIA PHARMACEUTICALS INC (ACAD) receives a "Hold" rating with a composite score of 55.1/100. It ranks #1258 out of 7,333 stocks in our coverage universe and carries a 3-star rating. Ratings are driven by a 6-factor quantitative model measuring quality, value, momentum, investment, stability, and short interest.
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YOY expansion rate
Core pricing power
Operating efficiency
Bottom-line conversion
Equity capital efficiency
Asset base utilization
Financial leverage load
Direct cash return
Stephen R. Davis
Chief Executive Officer
Labor Force
510
71
35
72
Audit Verdict: Average governance indicators based on financial metrics.
No recent insider transactions available for ACAD
HQ Base
SAN DIEGO, California
In-line with peers — no strong momentum signal
Trading at a discount to fundamentals — favorable entry valuation
High profitability & efficiency — strong quality floor supports entry
Low volatility — smoother ride and historically better risk-adjusted returns
Moderate investment profile
Mid-range overall rating
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Relative valuation derived from Manufacturing sector benchmarks. Model weights: EV/EBITDA (40%), P/B (35%), P/S (25%). Re-calculated daily.
Projection based on user-defined inputs. Re-calculated daily against current market data.
Reverse DCF Framework — Mauboussin Methodology
Institutional-grade Reverse DCF analysis. This model identifies the growth hurdles embedded in current market prices. When implied growth is significantly lower than historical or projected rates, a margin of safety may exist. Re-audited daily.
No analyst ratings for ACAD.
View All RatingsHigh margin volatility — erratic forensic earnings quality
| Factor | Global | Sector | Tilt |
|---|---|---|---|
| PROFITABILITY | 71 | 78 | -7DRAG |
| MOMENTUM | 55 | 46 | +9ALPHA |
| VALUATION | 64 | 51 | +13ALPHA |
| INVESTMENT | 35 | 58 | -23DRAG |
| STABILITY | 72 | 70 | +2NEUTRAL |
| SHORT INT | 21 | 5 | +16ALPHA |
Global = full universe. Sector = relative to industry peers. Positive tilt indicates idiosyncratic strength.
ROE proxy 16.4% (sector -2.5%)
GM 92% vs sector 43%, OM 11% vs sector 1%
Capital turnover N/A, R&D intensity 31.0%
Rev growth 15%, 10yr history
Interest coverage N/A, Net debt/EBITDA -6.0x
Composite assessment of profitability, capital efficiency, and financial strength. Top-tier entities demonstrate sustainable cash flow generation and elite competitive moats.
Profit generated per dollar of shareholder equity
Efficiency of asset utilization
Pricing power and cost efficiency
Core business profitability
Bottom-line profitability
The Quality factor evaluates the persistence and magnitude of realized cash flows. Companies with scores >70 exhibit superior pricing power and structural financial resilience through diverse economic regimes.
Our uncertainty rating tracks the predictability of future cash flows and potential for permanent capital loss. Moderate visibility with standard industry cyclicality.
Our model assigns ACADIA PHARMACEUTICALS INC a Hold rating, with a composite score of 55.1/100 and 3 out of 5 stars. Ranked #1258 of 7,333 stocks, ACAD presents a mixed quantitative picture — neither compelling enough to initiate new positions nor weak enough to warrant selling. Investors already holding may consider maintaining their position while monitoring for changes in the factor profile.
ACAD earns a quality score of 71/100, indicating above-average business quality. The company reports a return on equity of 16.4% (sector avg: -2.5%), gross margins of 92.1% (sector avg: 42.5%), net margins of 14.2% (sector avg: -0.2%). Companies in this tier generally demonstrate consistent profitability and efficient capital deployment, though they may face some competitive pressure.
ACAD's value score of 64/100 indicates the stock is fairly valued based on its current fundamentals. Key valuation metrics include a P/E ratio of 27.02x, an EV/EBITDA of 34.09x, a P/B ratio of 4.42x. At this level, neither a clear bargain nor overpriced, the stock's attractiveness depends more on forward growth expectations and qualitative factors.
ACADIA PHARMACEUTICALS INC's investment score of 35/100 suggests limited reinvestment activity. Key growth metrics include revenue growth of 15.2% vs. a sector average of 5.9% and a return on assets of 11.3% (sector: -0.1%). While this can be positive for mature, cash-generative businesses returning capital to shareholders, it may also signal a lack of growth opportunities or management conservatism.
ACAD demonstrates moderate momentum with a score of 55/100, suggesting a neutral price trend without strong directional conviction. Revenue growth stands at 15.2% year-over-year, while a beta of 0.86 reflects its sensitivity to broader market moves. Moderate momentum may indicate the stock is consolidating or transitioning between trends, warranting close monitoring of upcoming catalysts.
ACAD shows good financial stability with a score of 72/100. Key stability metrics include a beta of 0.86 and a debt-to-equity ratio of 45.00x (sector avg: 0.2x). This suggests manageable leverage and moderate price volatility, making it appropriate for investors seeking a balance between growth potential and capital preservation.
ACADIA PHARMACEUTICALS INC's short interest score of 21/100 reveals significant bearish positioning, suggesting institutional investors are actively betting against the stock. Specific risk factors include elevated leverage (D/E: 45.00x). At $3.6B (mid-cap), ACAD carries meaningful risk and is best suited for investors with high risk tolerance who have thoroughly evaluated the bear thesis.
ACADIA PHARMACEUTICALS INC is a mid-cap company in the Manufacturing sector, ranked #0 of 50 in its sector (100th percentile) and #1258 of 7,333 overall (83rd percentile). Key comparisons include ROE of 16.4% exceeding the -2.5% sector median and operating margins of 11.4% above the 1.3% sector average. This top-quartile standing reflects exceptional competitive strength relative to Manufacturing peers.
While ACAD currently exhibits a HOLD profile, superior opportunities exist within the MANUFACTURING sector. Our model identifies several "Strong Buy" candidates with higher quality scores and more attractive valuations among direct industry competitors.
View Top Manufacturing Alpha →Quant Factor Profile
Key factor gap
Stability (72) vs Short Int. (21) — closing this gap could shift the rating.
EV/EBITDA 197% ABOVE SECTOR MEDIAN
ROE 760% BELOW SECTOR MEDIAN
Gross Margin 117% ABOVE SECTOR MEDIAN (FAVORABLE)
AUDIT DATA AS OF SEP 30, 2025 (Q2 FY2025)
We rate ACADIA PHARMACEUTICALS INC (ACAD) as a Hold with a composite score of 55.1/100 at a current price of $24.59. The stock presents a mixed quantitative picture — neither compelling enough to warrant new accumulation nor weak enough to justify selling for existing holders. Our factors are split, and the overall profile suggests patience is warranted.
The rating is primarily driven by strength in stability (72th percentile) and quality (71th percentile), which together account for the majority of the composite score. Offsetting weakness in investment (35th percentile) and momentum (55th percentile) tempers our overall conviction. We assign a Narrow Moat rating (58/100), Low uncertainty, and Standard capital allocation.
Key items to watch: quarterly earnings execution and sector-level competitive dynamics. Any material change in these dynamics could warrant a reassessment of our rating. The moat trend is widening, which provides additional comfort in the durability of the competitive position.
ACADIA PHARMACEUTICALS INC holds a top-quartile position (#0 of 50) within the Manufacturing sector, based on our composite quantitative scoring across quality, value, momentum, and stability factors. The composite score of 55.1/100 places it at rank #1258 in our full 7,333-stock universe. At $3.6B in market capitalization, ACADIA PHARMACEUTICALS INC is a mid-cap player in the Manufacturing space, which limits certain scale advantages but may allow for more agile strategic execution.
Revenue is growing at 15%, though momentum at the 55th percentile suggests the market has not yet fully recognized this trajectory. This potential disconnect between fundamental improvement and market recognition could represent an opportunity for patient investors if the growth trend persists.
The margin cascade tells an important story: gross margins of 92% (+49.6pp vs sector) narrow to operating margins of 11% (+10.1pp vs sector) and net margins of 14.2%, yielding a gross-to-net conversion rate of 15%. This conversion rate is typical for the sector, suggesting a standard cost structure without notable efficiency advantages or disadvantages.
At a current price of $24.59, ACADIA PHARMACEUTICALS INC is trading near fair value based on current fundamentals. Our value factor score of 64/100 reflects a composite assessment across multiple valuation metrics including price-to-earnings, price-to-book, EV/EBITDA, and price-to-sales ratios relative to both sector peers and the broader market. Valuation metrics are mixed, with no strong signal of mispricing in either direction.
The stock currently trades at a P/E of 27.0x (a 21% premium to the sector median of 22.3x), EV/EBITDA of 34.1x (at a premium), P/B of 4.4x, P/S of 3.9x. The above-sector P/E multiple suggests the market is pricing in superior growth or quality, which our analysis partially supports given strong quality metrics.
Gross margins of 92% signal strong pricing power and brand/IP advantages — businesses with margins above 40% have historically demonstrated more resilient earnings through economic cycles.
Returns on equity of 16.4% exceed the cost of equity for most companies, indicating genuine shareholder value creation and a reinvestment engine that compounds wealth over time.
Revenue growth of 15% confirms the business is expanding its addressable market — growth at this level typically supports multiple expansion and attracts institutional capital.
Return on assets of 11.3% indicates efficient deployment of the full asset base, not just equity capital.
Even high-quality stocks face risks from valuation compression, competitive disruption, or macro shocks that are difficult to quantify in advance.
We assign a Low uncertainty rating to ACADIA PHARMACEUTICALS INC. The company exhibits strong financial stability with a beta of 0.86, conservative leverage (45% D/E), and a stability factor in the 72th percentile. The predictable nature of the business model and solid financial position reduce the range of potential outcomes, giving us confidence in our fair value estimate.
We identify no major risk factors at this time. The company's stability factor sits at the 72th percentile with quality at the 71th percentile, both of which support our low-risk assessment. The absence of material leverage, profitability, or volatility concerns reduces the likelihood of a permanent capital loss scenario.
Key risk mitigants include: healthy gross margins of 92% provide a buffer against cost pressures; above-average stability (72th percentile) suggests predictable business dynamics. These factors partially offset the identified risks and provide downside protection in adverse scenarios. On balance, the risk-reward profile is favorable for long-term investors.
We rate ACADIA PHARMACEUTICALS INC's capital allocation as Standard. Management has shown adequate — though not exceptional — stewardship of shareholder capital. Returns on equity stand at 16.4%, and the balance sheet is managed within acceptable parameters (D/E: 45%). Exemplary allocators typically sustain ROE above 20% and D/E below 50%; ACADIA PHARMACEUTICALS INC falls short on at least one dimension.
There is room for improvement in optimizing the capital structure or enhancing shareholder returns. Absent a dividend, the overall capital allocation framework would benefit from either higher reinvestment returns, improved balance sheet efficiency, or increased shareholder distributions. We will monitor for signs of strategic improvement that could warrant an upgrade.
In summary, ACADIA PHARMACEUTICALS INC receives a Hold rating with a composite score of 55.1/100 (rank #1258 of 7,333). Our quantitative framework assigns a Narrow Moat (58/100, trend: widening), Low uncertainty, and Standard capital allocation. The average factor score across quality, value, momentum, stability, and investment is 59/100.
Our analysis supports a neutral stance on ACADIA PHARMACEUTICALS INC. While the quantitative profile is not weak enough to warrant selling, it lacks the multi-factor strength required for a buy recommendation. Existing holders should maintain positions and monitor for catalysts — either fundamental improvement or valuation compression — that would shift the risk-reward balance.
Analysis derived from Blank Capital Research quantitative terminal. For informational purposes only. No trade solicitation. Past performance not indicative of future results. Consult a qualified advisor.
We assign ACADIA PHARMACEUTICALS INC a Narrow Moat rating with a composite moat score of 58/100. The company possesses identifiable competitive advantages, though they are less entrenched than those of wide-moat peers. Our analysis indicates that ACADIA PHARMACEUTICALS INC can sustain above-average returns on invested capital for at least 10 years, with the strongest contributor being margin superiority at 18.3/20.
The strongest moat sources are margin superiority (18.3/20) and growth durability (17.3/20). GM 92% vs sector 43%, OM 11% vs sector 1%. Rev growth 15%, 10yr history. These pillars form the core of ACADIA PHARMACEUTICALS INC's competitive identity and are the primary drivers of excess returns in our framework.
Areas of relative weakness include reinvestment efficiency (7/20) and financial resilience (7.7/20). Capital turnover N/A, R&D intensity 31.0%. Improvement in these areas could meaningfully widen the moat over time, while deterioration would be an early warning of competitive erosion.
Our moat trend assessment is Widening. ROIC has trended upward at ~20.4pp per year, and operating margin trajectory confirms strengthening economics. ACADIA PHARMACEUTICALS INC's competitive position is improving on a fundamental basis. We expect the moat score to drift upward if these trends persist over the next 12–18 months.
Key profit drivers include gross margins of 92% providing a solid profitability foundation, operating margins of 11% reflecting effective cost management, robust top-line growth of 15% expanding the revenue base. The margin cascade from 92% gross to 11% operating to 14.2% net reveals the company's cost structure and reinvestment intensity. Our analysis indicates that the profit engine is high-quality and likely sustainable, with the quality factor at the 71th percentile.
The margin profile shows gross margins of 92%, operating margins of 11%, net margins of 14.2%. Return metrics include ROE of 16.4% and ROA of 11.3%. Relative to the Manufacturing sector, gross margins are 49.6 percentage points above the sector median of 43%, and ROE of 16.4% compares to a sector median of -2.5%.
The balance sheet reflects moderate leverage with D/E of 45%, revenue growth of 15%. The sector median D/E is 0%, putting ACADIA PHARMACEUTICALS INC at higher leverage than the typical peer. The combination of low leverage and healthy profitability provides significant financial resilience and strategic optionality.
In recent days, ACADIA Pharmaceuticals drew fresh attention after Wall Street analysts reacted to updates on its neurology and rare‑disease pipeline, highlighting the company’s transition from a single‑product focus to a broader portfolio with additional development‑stage and deal‑driven assets. This shift toward a more diversified set of neurology and genetic disorder programs has become a key talking point among analysts assessing how ACADIA balances Nuplazid’s importance with new...
SAN DIEGO, February 23, 2026--Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) today announced that it will participate at three upcoming investor conferences:

Top Wall Street analysts changed their outlook on these top names. For a complete view of all analyst rating changes, including upgrades, downgrades and initiations, please see our analyst ratings page. BMO Capital analyst Keith Tapper initiated coverage on ACADIA Pharmaceuticals Inc. (NASDAQ:ACAD) with an Outperform rating and announced a price target of $31. ACADIA Pharmaceuticals shares fell 0.6% to close at $15.50 on Wednesday. See how other analysts view this stock. Mizuho analyst Wei Fang initiated coverage on Grab Holdings Limited (NASDAQ:GRAB) with an Outperform rating and announced a price target of $5. Grab shares fell 0.3% to ...Full story available on Benzinga.com
Acadia Pharma (ACAD) reports Q4 earnings Feb 25 after close.
Above 50MA
37.18%
Net New Highs
+51081