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Verdict
Quantitative factor alignment verified for current market regime.
Quant Score
Rank
#360
Positioning
Market Dominance
Manufacturing
Pharmaceutical Products
$76M
Lloyd M. Segal
Repare Therapeutics Inc., a clinical-stage precision oncology company, discovers and develops therapeutics by using its synthetic lethality approach. Its lead product candidate is an oral small molecule inhibitor for the treatment of solid tumors with specific DNA damage repair-related genomic alterations. The company was incorporated in 2016 and is headquartered in Montreal, Canada.
Headcount
180
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X-AXIS: EV/EBITDA (LOWER = CHEAPER) | Y-AXIS: ROE (HIGHER = ELITE) | RED CIRCLE = RPTX ANALYSIS TARGET
| Stock | Rating | Score▼ | Quality | Value | Momentum | P/E | EV/EBITDA | ROE | ROA | Gross Mgn | Op Mgn | Net Mgn | Rev Growth | Div Yield | D/E | Mkt Cap | AUDIT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
$UL UNILEVER PLC | 78 | 96 | 98 | 59 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$ASML ASML HOLDING NV | 77 | 89 | 86 | 83 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$ESLT ELBIT SYSTEMS LTD | 76 | 81 | 87 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$MT ArcelorMittal | 75 | 71 | 98 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$AMAT APPLIED MATERIALS INC /DE | 75 | 85 | 87 | 84 | 20.9x | 13.6x | 32.9% | 20.5% | 48.8% | 30.6% | 24.4% | 7.7% | 0.9% | 32.0x | $148.6B | VS | |
$SIMO Silicon Motion Technology CORP | 75 | 84 | 86 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$CODA Coda Octopus Group, Inc. | 74 | 83 | 90 | 79 | 16.3x | 11.9x | 7.4% | 7.5% | 68.3% | 19.5% | 18.2% | 29.0% | 0.0% | 0.0x | $84M | VS | |
$GSK GSK plc | 74 | 84 | 90 | 70 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$EFXT Enerflex Ltd. | 74 | 80 | 91 | 83 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$BUD Anheuser-Busch InBev SA/NV | 74 | 84 | 97 | 63 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$RPTX Repare Therapeutics Inc. | 64 | 61 | 74 | 83 | 5.8x | 24.5x | -49.8% | 2.0% | 100.0% | 9.7% | 28.0% | - | 0.0% | 0.0x | $76M | ||
| SECTOR BENCH | - | - | - | - | - | 22.3x | 11.5x | -1.9% | 0.9% | 44.1% | 2.5% | 1.0% | 6.7% | 0.0% | 0.2x | - | REF |
Repare Therapeutics Inc. (RPTX) receives a "Hold" rating with a composite score of 63.8/100. It ranks #360 out of 7,333 stocks in our coverage universe and carries a 3-star rating. Ratings are driven by a 6-factor quantitative model measuring quality, value, momentum, investment, stability, and short interest.
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HQ Base
Pending Verification
Outperforming peers — winners tend to keep winning over 3-12 months
Trading at a discount to fundamentals — favorable entry valuation
High profitability & efficiency — strong quality floor supports entry
Low volatility — smoother ride and historically better risk-adjusted returns
Moderate investment profile
Mid-range overall rating
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Relative valuation derived from Manufacturing sector benchmarks. Model weights: EV/EBITDA (40%), P/B (35%), P/S (25%). Re-calculated daily.
Projection based on user-defined inputs. Re-calculated daily against current market data.
Reverse DCF Framework — Mauboussin Methodology
Institutional-grade Reverse DCF analysis. This model identifies the growth hurdles embedded in current market prices. When implied growth is significantly lower than historical or projected rates, a margin of safety may exist. Re-audited daily.
No analyst ratings for RPTX.
View All Ratings| Factor | Global | Sector | Tilt |
|---|---|---|---|
| PROFITABILITY | 61 | 66 | -5NEUTRAL |
| MOMENTUM | 83 | 90 | -7DRAG |
| VALUATION | 74 | 77 | -3NEUTRAL |
| INVESTMENT | 36 | 66 | -30DRAG |
| STABILITY | 75 | 77 | -2NEUTRAL |
| SHORT INT | 59 | 70 | -11DRAG |
Global = full universe. Sector = relative to industry peers. Positive tilt indicates idiosyncratic strength.
ROE proxy -49.8% (sector -1.9%)
GM 100% vs sector 44%, OM 10% vs sector 3%
Capital turnover N/A
Rev growth N/A, 6yr history
Interest coverage N/A
Composite assessment of profitability, capital efficiency, and financial strength. Top-tier entities demonstrate sustainable cash flow generation and elite competitive moats.
Profit generated per dollar of shareholder equity
Efficiency of asset utilization
Pricing power and cost efficiency
Core business profitability
Bottom-line profitability
The Quality factor evaluates the persistence and magnitude of realized cash flows. Companies with scores >70 exhibit superior pricing power and structural financial resilience through diverse economic regimes.
Our uncertainty rating tracks the predictability of future cash flows and potential for permanent capital loss. Moderate visibility with standard industry cyclicality.
We rate Repare Therapeutics Inc. (RPTX) as a Hold with a composite score of 63.8/100 at a current price of $2.65. The stock presents a mixed quantitative picture — neither compelling enough to warrant new accumulation nor weak enough to justify selling.
Repare Therapeutics Inc. holds a top-quartile position (#0 of 50) within the Manufacturing sector, based on our composite quantitative scoring across quality, value, momentum, and stability factors. The composite score of 63.8/100 places it at rank #360 in our full universe.
No Moat
Low
Standard
Undervalued
Gross margins of 100% signal strong pricing power.
Value factor score of 74 suggests attractive pricing.
Positive momentum indicates institutional accumulation.
Vulnerability to macroeconomic shocks and interest rate volatility.
Repare Therapeutics Inc. represents a hold based on multi-factor quantitative performance.
Our model assigns Repare Therapeutics Inc. a Hold rating, with a composite score of 63.8/100 and 3 out of 5 stars. Ranked #360 of 7,333 stocks, RPTX presents a mixed quantitative picture — neither compelling enough to initiate new positions nor weak enough to warrant selling. Investors already holding may consider maintaining their position while monitoring for changes in the factor profile.
With a quality score of 61/100, RPTX shows adequate but unremarkable business quality. The company reports a return on equity of -49.8% (sector avg: -1.9%), gross margins of 100.0% (sector avg: 44.1%), net margins of 28.0% (sector avg: 1.0%). This suggests the company generates acceptable returns but may lack the competitive positioning or operational efficiency to stand out from peers.
RPTX carries a solid value score of 74/100, pointing to an attractively priced stock relative to peers. Key valuation metrics include a P/E ratio of 5.80x, an EV/EBITDA of 24.52x, a P/B ratio of 0.66x. This score suggests reasonable compensation for the risks involved, with potential upside if the market recognizes the stock's underlying worth.
Repare Therapeutics Inc.'s investment score of 36/100 suggests limited reinvestment activity. Key growth metrics include a return on assets of 2.0% (sector: 0.9%). While this can be positive for mature, cash-generative businesses returning capital to shareholders, it may also signal a lack of growth opportunities or management conservatism.
RPTX shows strong momentum characteristics with a score of 83/100. The stock has been trending above key moving averages, indicating solid demand from institutional buyers. Revenue growth data is not currently available. This level of momentum typically signals sustained investor confidence and favorable near-term price action.
RPTX shows good financial stability with a score of 75/100. Key stability metrics include a debt-to-equity ratio of 0.00x (sector avg: 0.2x). This suggests manageable leverage and moderate price volatility, making it appropriate for investors seeking a balance between growth potential and capital preservation.
The short interest score of 59/100 for RPTX suggests somewhat elevated bearish positioning by institutional traders. Specific risk factors include micro-cap liquidity risk. With a $76M market cap (micro-cap), Repare Therapeutics Inc. may experience above-average volatility. Investors should consider whether the short thesis has merit or if it creates a potential short-squeeze opportunity.
Repare Therapeutics Inc. is a micro-cap company in the Manufacturing sector, ranked #0 of 50 in its sector (100th percentile) and #360 of 7,333 overall (95th percentile). Key comparisons include ROE of -49.8% trailing the -1.9% sector median and operating margins of 9.7% above the 2.5% sector average. This top-quartile standing reflects exceptional competitive strength relative to Manufacturing peers.
While RPTX currently exhibits a HOLD profile, superior opportunities exist within the MANUFACTURING sector. Our model identifies several "Strong Buy" candidates with higher quality scores and more attractive valuations among direct industry competitors.
View Top Manufacturing Alpha →Quant Factor Profile
Key factor gap
Momentum (83) vs Investment (36) — closing this gap could shift the rating.
EV/EBITDA 114% ABOVE SECTOR MEDIAN
ROE 2520% ABOVE SECTOR MEDIAN (FAVORABLE)
Gross Margin 127% ABOVE SECTOR MEDIAN (FAVORABLE)
Above 50MA
37.18%
Net New Highs
+51081

Repare Therapeutics Inc. has announced the completion of its acquisition by XenoTherapeutics, Inc. and Xeno Acquisition Corp. Shareholders received approximately US$2.20 per common share, plus one non-transferable contingent value right (CVR). The common shares are expected to cease trading on the Nasdaq Global Select Market around January 28, 2026.
Repare Therapeutics announced its intention to delist and deregister its shares from Nasdaq following the closing of a transaction on January 28, 2026. The company requested a suspension of trading and will file Form 25 for delisting, with the purchaser also planning to file Form 15 to terminate SEC reporting obligations. This action follows an original SEC Filing by Repare Therapeutics Inc. (RPTX) on the same date.

Repare Therapeutics shareholders have approved the acquisition of all outstanding common shares by XenoTherapeutics Inc., a non-profit biotechnology group, with 99.76% of votes in favor. They also approved executive compensation related to the transaction and contingency plans for liquidation through KPMG if the deal fails. The recent analyst rating for RPTX stock is a Hold with a $3.00 price target, while TipRanks’ AI Analyst, Spark, rates it Neutral due to weak financial performance tempered by a strong balance sheet and positive corporate developments.
Repare Therapeutics stock surged 18% in premarket trading after announcing a definitive asset purchase agreement with Gilead Sciences for its cancer drug RP-3467. The deal includes up to $30 million in consideration, enhancing Repare's cash balance and increasing the estimated per-share payout for shareholders in its upcoming acquisition by XenoTherapeutics to approximately $2.20. This marks Repare's third and most significant portfolio transaction of the year.
Repare Therapeutics (RPTX) has sold its polymerase theta ATPase inhibitor, RP-3467, to Gilead Sciences (GILD) for up to $30 million. This deal, which includes a $25 million upfront payment, strengthens Repare's cash balance and is expected to impact its pending acquisition by Xeno Therapeutics, with shareholders potentially receiving US$2.20 per share. RP-3467 is being evaluated in the POLAR Phase 1 trial for various advanced cancers, and the acquisition highlights Gilead's focus on oncology and synthetic lethality.