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Verdict
Quantitative factor alignment verified for current market regime.
Quant Score
Rank
#3200
Positioning
Market Dominance
Manufacturing
Pharmaceutical Products
$62M
Yuichi Iwaki
MediciNova, Inc. focuses on developing novel and small molecule therapeutics for the treatment of serious diseases with unmet medical needs in the United States. The company is developing MN-166 (ibudilast), an oral anti-inflammatory and neuroprotective agent for treating neurological disorders. MN-221 (bedoradrine), a selective beta-2-adrenergic receptor agonist for the. treatment of acute exacerbations of asthma, MN-001 (tipelukast) is an orally bioavailable small molecule compound to treat fibrotic diseases.
Headcount
10
HQ Base
LA JOLLA, California
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| Stock | Rating | Score▼ | Quality | Value | Momentum | P/E | EV/EBITDA | ROE | ROA | Gross Mgn | Op Mgn | Net Mgn | Rev Growth | Div Yield | D/E | Mkt Cap | AUDIT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
$UL UNILEVER PLC | 78 | 96 | 98 | 59 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$ASML ASML HOLDING NV | 77 | 89 | 86 | 83 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$ESLT ELBIT SYSTEMS LTD | 76 | 81 | 87 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$MT ArcelorMittal | 75 | 71 | 98 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$AMAT APPLIED MATERIALS INC /DE | 75 | 85 | 87 | 84 | 20.9x | 13.6x | 32.9% | 20.5% | 48.8% | 30.6% | 24.4% | 7.7% | 0.9% | 32.0x | $148.6B | VS | |
$SIMO Silicon Motion Technology CORP | 75 | 84 | 86 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$CODA Coda Octopus Group, Inc. | 74 | 83 | 90 | 79 | 16.3x | 11.9x | 7.4% | 7.5% | 68.3% | 19.5% | 18.2% | 29.0% | 0.0% | 0.0x | $84M | VS | |
$GSK GSK plc | 74 | 84 | 90 | 70 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$EFXT Enerflex Ltd. | 74 | 80 | 91 | 83 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$BUD Anheuser-Busch InBev SA/NV | 74 | 84 | 97 | 63 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$MNOV MEDICINOVA INC | 42 | 35 | 28 | 45 | - | - | -27.4% | -25.3% | 100.0% | -2710.8% | -2455.7% | - | 0.0% | 8.0x | $62M | ||
| SECTOR BENCH | - | - | - | - | - | 22.3x | 11.5x | -1.9% | 0.9% | 44.1% | 2.5% | 1.0% | 6.7% | 0.0% | 0.2x | - | REF |
MEDICINOVA INC (MNOV) receives a "Reduce" rating with a composite score of 42.4/100. It ranks #3200 out of 7,333 stocks in our coverage universe and carries a 2-star rating. Ratings are driven by a 6-factor quantitative model measuring quality, value, momentum, investment, stability, and short interest.
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In-line with peers — no strong momentum signal
Expensive relative to fundamentals — limited margin of safety
Average quality profile
Average volatility — neutral timing signal
Aggressive spending — empire-building risk, dilutive growth
Mid-range overall rating
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Relative valuation derived from Manufacturing sector benchmarks. Model weights: EV/EBITDA (40%), P/B (35%), P/S (25%). Re-calculated daily.
No analyst ratings for MNOV.
View All RatingsROE proxy -27.4% (sector -1.9%)
GM 100% vs sector 44%, OM -2711% vs sector 3%
Capital turnover N/A, R&D intensity 2016.1%
Rev growth N/A, 10yr history
Interest coverage N/A
Composite assessment of profitability, capital efficiency, and financial strength. Top-tier entities demonstrate sustainable cash flow generation and elite competitive moats.
Profit generated per dollar of shareholder equity
Efficiency of asset utilization
Pricing power and cost efficiency
Core business profitability
Bottom-line profitability
The Quality factor evaluates the persistence and magnitude of realized cash flows. Companies with scores >70 exhibit superior pricing power and structural financial resilience through diverse economic regimes.
Our uncertainty rating tracks the predictability of future cash flows and potential for permanent capital loss. Moderate visibility with standard industry cyclicality.
We rate MEDICINOVA INC (MNOV) as a Reduce with a composite score of 42.4/100 at a current price of $1.36. The quantitative profile shows weakness across multiple dimensions, suggesting limited upside potential.
MEDICINOVA INC holds a top-quartile position (#0 of 50) within the Manufacturing sector, based on our composite quantitative scoring across quality, value, momentum, and stability factors. The composite score of 42.4/100 places it at rank #3200 in our full universe.
No Moat
Medium
Poor
Fair Value
Gross margins of 100% signal strong pricing power.
Stable competitive position in a defensive sector.
Vulnerability to macroeconomic shocks and interest rate volatility.
MEDICINOVA INC represents a reduce based on multi-factor quantitative performance.
MEDICINOVA INC receives a Reduce rating from our analysis, with a composite score of 42.4/100 and 2 out of 5 stars, ranking #3200 out of 7,333 stocks. MNOV's factor profile shows weakness across multiple dimensions, suggesting the stock may underperform going forward. Existing holders may want to consider trimming positions or tightening stop-losses.
MNOV's quality score of 35/100 is below average, suggesting challenges with profitability or capital efficiency. The company reports a return on equity of -27.4% (sector avg: -1.9%), gross margins of 100.0% (sector avg: 44.1%), net margins of -2455.7% (sector avg: 1.0%). Investors should examine whether management is actively addressing these weaknesses or if they reflect structural industry headwinds.
MNOV registers a value score of just 28/100, suggesting the stock trades at a significant premium to its fundamental metrics. Key valuation metrics include a P/B ratio of 1.68x. High-premium valuations like this require strong future execution to avoid multiple compression, and downside risk is elevated if growth disappoints.
MEDICINOVA INC's investment score of 25/100 suggests limited reinvestment activity. Key growth metrics include a return on assets of -25.3% (sector: 0.9%). While this can be positive for mature, cash-generative businesses returning capital to shareholders, it may also signal a lack of growth opportunities or management conservatism.
MNOV is currently showing below-average momentum at 45/100, which may indicate weakening institutional interest or negative sentiment shifts. Revenue growth data is not currently available, while a beta of 0.64 reflects its sensitivity to broader market moves. Investors should note that declining momentum can precede further price weakness, though contrarian opportunities sometimes emerge at these levels.
With a stability score of 58/100, MNOV exhibits average financial resilience. Key stability metrics include a beta of 0.64 and a debt-to-equity ratio of 8.00x (sector avg: 0.2x). While the balance sheet is not a major concern, the stock is subject to typical market volatility and may experience sharper drawdowns during risk-off episodes.
MNOV carries a short interest score of 75/100, indicating moderate short selling activity. This is a neutral reading — not enough to signal systemic bearishness, but worth monitoring. Specific risk factors include elevated leverage (D/E: 8.00x), micro-cap liquidity risk. At $62M market cap (micro-cap), MEDICINOVA INC offers reasonable institutional liquidity.
MEDICINOVA INC is a micro-cap company in the Manufacturing sector, ranked #0 of 50 in its sector (100th percentile) and #3200 of 7,333 overall (56th percentile). Key comparisons include ROE of -27.4% trailing the -1.9% sector median and operating margins of -2710.8% below the 2.5% sector average. This top-quartile standing reflects exceptional competitive strength relative to Manufacturing peers.
While MNOV currently exhibits a REDUCE profile, superior opportunities exist within the MANUFACTURING sector. Our model identifies several "Strong Buy" candidates with higher quality scores and more attractive valuations among direct industry competitors.
View Top Manufacturing Alpha →Quant Factor Profile
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Improvement in Investment (25) would have the largest impact on the composite score.
ROE 1342% ABOVE SECTOR MEDIAN (FAVORABLE)
Gross Margin 127% ABOVE SECTOR MEDIAN (FAVORABLE)
Op. Margin 108099% BELOW SECTOR MEDIAN
Above 50MA
37.18%
Net New Highs
+51081

MediciNova (NASDAQ:MNOV) reported quarterly earnings of ($0.05) EPS, surpassing analyst estimates by $0.05, with revenue of $0.15 million. The biopharmaceutical company's shares traded down 0.7% to $1.54, giving it a market capitalization of $75.64 million. Analysts maintain a "Moderate Buy" consensus rating with an average price target of $7.00.
MediciNova Inc. (MNOV:NASDAQ) announced significant progress in its SEANOBI study for ALS, with 100 patients enrolled across 12 sites in the U.S., reaching 50% of its target. The study, funded by a US$22 million NINDS grant, evaluates ibudilast (MN 166) in ALS patients not eligible for randomized trials, aiming to gather critical real-world biomarker and clinical outcome data. This expanded access program complements the ongoing COMBAT ALS Phase 2b/3 trial, with both studies providing evidence to support future regulatory discussions for ibudilast as an ALS treatment.

MediciNova (NASDAQ:MNOV) announced that 100 patients have been enrolled in the NIH-funded SEANOBI Expanded-Access Program (EAP) evaluating MN-166 (ibudilast) for ALS, reaching 50% of its 200-patient goal across 12 US sites. This program, backed by a $22 million NINDS grant, provides real-world biomarker and clinical outcome data, complementing the ongoing COMBAT-ALS Phase 2b/3 randomized trial, which is fully enrolled with 234 patients and expects topline results by the end of 2026. The SEANOBI EAP aims to offer MN-166 access to ALS patients who are not eligible for randomized trials.

Lucid Cap Mkts has upgraded MediciNova (NASDAQ:MNOV) to a "strong-buy" rating. Despite mixed analyst opinions, the stock holds a consensus "Moderate Buy" rating with an average price target of $7.00. MediciNova is a clinical-stage biopharmaceutical company focusing on small-molecule therapeutics, with its lead asset MN-166 (ibudilast) being a key focus.

MediciNova (NASDAQ:MNOV) has announced an equity distribution agreement with Lucid Capital Markets, allowing them to sell up to $50 million of common stock through at-the-market offerings. This move is necessitated by the biotechnology company's significant cash burn, with a negative free cash flow of $9.73 million over the past year. The agreement provides financial flexibility as MediciNova continues to advance its clinical trials for MN-166 in conditions like chemotherapy-induced peripheral neuropathy and amyotrophic lateral sclerosis.