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Verdict
Quantitative factor alignment verified for current market regime.
Quant Score
Rank
#1228
Positioning
Market Dominance
Manufacturing
Pharmaceutical Products
$1.6B
John C.s Jacobs
Harmony Biosciences Holdings, Inc. develops and commercializes therapies for patients with rare neurological disorders in the United States. WAKIX is a medication for the treatment of excessive daytime sleepiness in adult patients with narcolepsy.
Headcount
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X-AXIS: EV/EBITDA (LOWER = CHEAPER) | Y-AXIS: ROE (HIGHER = ELITE) | RED CIRCLE = HRMY ANALYSIS TARGET
| Stock | Rating | Score▼ | Quality | Value | Momentum | P/E | EV/EBITDA | ROE | ROA | Gross Mgn | Op Mgn | Net Mgn | Rev Growth | Div Yield | D/E | Mkt Cap | AUDIT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
$UL UNILEVER PLC | 78 | 96 | 98 | 59 | - | - | 28.5% | 8.0% | 100.0% | 100.0% | 10.4% | -4.6% | 3.3% | 0.0x | $141.8B | VS | |
$ASML ASML HOLDING NV | 77 | 89 | 86 | 83 | - | - | 46.1% | 16.6% | 51.3% | 31.9% | 26.8% | -4.0% | 1.0% | 25.0x | $272.1B | VS | |
$ESLT ELBIT SYSTEMS LTD | 76 | 81 | 87 | 85 | - | - | 10.3% | 3.1% | 24.1% | 7.2% | 4.7% | 14.3% | 0.8% | 25.0x | $11.4B | VS | |
$MT ArcelorMittal | 75 | 71 | 98 | 85 | - | - | 2.2% | 1.5% | 9.3% | 5.3% | 2.2% | -8.5% | 2.2% | 16.0x | $18.9B | VS | |
$AMAT APPLIED MATERIALS INC /DE | 75 | 85 | 87 | 84 | 20.9x | 13.6x | 35.5% | 19.8% | 48.7% | 29.2% | 24.7% | 4.4% | 0.8% | 32.0x | $181.9B | VS | |
$SIMO Silicon Motion Technology CORP | 75 | 84 | 86 | 85 | - | - | 11.8% | 8.8% | 45.9% | 11.3% | 11.1% | 25.7% | 3.7% | 0.0x | $1.8B | VS | |
$CODA Coda Octopus Group, Inc. | 74 | 83 | 90 | 79 | 16.3x | 11.9x | 7.6% | 7.0% | 66.5% | 17.1% | 15.6% | 39.0% | 0.0% | 0.0x | $115M | VS | |
$GSK GSK plc | 74 | 84 | 90 | 70 | - | - | 22.6% | 4.9% | 71.2% | 12.8% | 9.4% | 1.7% | 5.9% | 124.0x | $72.1B | VS | |
$EFXT Enerflex Ltd. | 74 | 80 | 91 | 83 | - | - | 3.0% | 1.1% | 20.9% | 7.3% | 1.3% | 3.0% | 0.9% | 67.0x | $1.2B | VS | |
$BUD Anheuser-Busch InBev SA/NV | 74 | 84 | 97 | 63 | - | - | 8.2% | 3.5% | 55.3% | 25.9% | 12.4% | 0.7% | 1.7% | 0.0x | $87.0B | VS | |
$HRMY Harmony Biosciences Holdings, Inc. | 55 | 81 | 91 | 33 | 9.2x | 8.0x | 21.8% | 15.1% | 78.9% | 28.7% | 22.6% | 38.6% | 0.0% | 20.0x | $1.6B | ||
| SECTOR BENCH | - | - | - | - | - | 22.3x | 11.5x | -2.5% | -0.1% | 42.5% | 1.3% | -0.2% | 5.9% | 0.0% | 0.2x | - | REF |
Harmony Biosciences Holdings, Inc. (HRMY) receives a "Hold" rating with a composite score of 55.3/100. It ranks #1228 out of 7,333 stocks in our coverage universe and carries a 3-star rating. Ratings are driven by a 6-factor quantitative model measuring quality, value, momentum, investment, stability, and short interest.
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YOY expansion rate
Core pricing power
Operating efficiency
Bottom-line conversion
Equity capital efficiency
Asset base utilization
Financial leverage load
Direct cash return
John C.s Jacobs
Chief Executive Officer
Labor Force
200
81
25
68
Audit Verdict: Average governance indicators based on financial metrics.
No recent insider transactions available for HRMY
200
HQ Base
Pending Verification
Lagging peers — losers tend to keep underperforming
Trading at a discount to fundamentals — favorable entry valuation
High profitability & efficiency — strong quality floor supports entry
Low volatility — smoother ride and historically better risk-adjusted returns
Aggressive spending — empire-building risk, dilutive growth
Mid-range overall rating
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Relative valuation derived from Manufacturing sector benchmarks. Model weights: EV/EBITDA (40%), P/B (35%), P/S (25%). Re-calculated daily.
Projection based on user-defined inputs. Re-calculated daily against current market data.
Reverse DCF Framework — Mauboussin Methodology
Institutional-grade Reverse DCF analysis. This model identifies the growth hurdles embedded in current market prices. When implied growth is significantly lower than historical or projected rates, a margin of safety may exist. Re-audited daily.
No analyst ratings for HRMY.
View All RatingsConservative accounting — High cash conversion efficiency
Improving capital utilization rates confirmed
High margin volatility — erratic forensic earnings quality
| Factor | Global | Sector | Tilt |
|---|---|---|---|
| PROFITABILITY | 81 | 91 | -10DRAG |
| MOMENTUM | 33 | 13 | +20ALPHA |
| VALUATION | 91 | 94 | -3NEUTRAL |
| INVESTMENT | 25 | 12 | +13ALPHA |
| STABILITY | 68 | 62 | +6ALPHA |
| SHORT INT | 33 | 22 | +11ALPHA |
Global = full universe. Sector = relative to industry peers. Positive tilt indicates idiosyncratic strength.
ROE proxy 21.8% (sector -2.5%)
GM 79% vs sector 43%, OM 29% vs sector 1%
Capital turnover N/A, R&D intensity 22.4%
Rev growth 39%, 6yr history
Interest coverage 18.1x, Net debt/EBITDA -7.3x
Composite assessment of profitability, capital efficiency, and financial strength. Top-tier entities demonstrate sustainable cash flow generation and elite competitive moats.
Profit generated per dollar of shareholder equity
Efficiency of asset utilization
Pricing power and cost efficiency
Core business profitability
Bottom-line profitability
The Quality factor evaluates the persistence and magnitude of realized cash flows. Companies with scores >70 exhibit superior pricing power and structural financial resilience through diverse economic regimes.
Our uncertainty rating tracks the predictability of future cash flows and potential for permanent capital loss. Moderate visibility with standard industry cyclicality.
Our model assigns Harmony Biosciences Holdings, Inc. a Hold rating, with a composite score of 55.3/100 and 3 out of 5 stars. Ranked #1228 of 7,333 stocks, HRMY presents a mixed quantitative picture — neither compelling enough to initiate new positions nor weak enough to warrant selling. Investors already holding may consider maintaining their position while monitoring for changes in the factor profile.
HRMY earns a quality score of 81/100, indicating above-average business quality. The company reports a return on equity of 21.8% (sector avg: -2.5%), gross margins of 78.9% (sector avg: 42.5%), net margins of 22.6% (sector avg: -0.2%). Companies in this tier generally demonstrate consistent profitability and efficient capital deployment, though they may face some competitive pressure.
From a valuation perspective, HRMY scores an exceptional 91/100, indicating the stock trades at a deep discount relative to its fundamentals. Key valuation metrics include a P/E ratio of 9.21x, an EV/EBITDA of 7.98x, a P/B ratio of 2.01x. A value score this high suggests the market may be significantly underpricing the company's earnings power, assets, or cash flow generation.
Harmony Biosciences Holdings, Inc.'s investment score of 25/100 suggests limited reinvestment activity. Key growth metrics include revenue growth of 38.6% vs. a sector average of 5.9% and a return on assets of 15.1% (sector: -0.1%). While this can be positive for mature, cash-generative businesses returning capital to shareholders, it may also signal a lack of growth opportunities or management conservatism.
HRMY is currently showing below-average momentum at 33/100, which may indicate weakening institutional interest or negative sentiment shifts. Revenue growth stands at 38.6% year-over-year, while a beta of 0.55 reflects its sensitivity to broader market moves. Investors should note that declining momentum can precede further price weakness, though contrarian opportunities sometimes emerge at these levels.
HRMY shows good financial stability with a score of 68/100. Key stability metrics include a beta of 0.55 and a debt-to-equity ratio of 20.00x (sector avg: 0.2x). This suggests manageable leverage and moderate price volatility, making it appropriate for investors seeking a balance between growth potential and capital preservation.
Harmony Biosciences Holdings, Inc.'s short interest score of 33/100 reveals significant bearish positioning, suggesting institutional investors are actively betting against the stock. Specific risk factors include elevated leverage (D/E: 20.00x), small-cap liquidity risk. At $1.6B (small-cap), HRMY carries meaningful risk and is best suited for investors with high risk tolerance who have thoroughly evaluated the bear thesis.
Harmony Biosciences Holdings, Inc. is a small-cap company in the Manufacturing sector, ranked #0 of 50 in its sector (100th percentile) and #1228 of 7,333 overall (83rd percentile). Key comparisons include ROE of 21.8% exceeding the -2.5% sector median and operating margins of 28.7% above the 1.3% sector average. This top-quartile standing reflects exceptional competitive strength relative to Manufacturing peers.
While HRMY currently exhibits a HOLD profile, superior opportunities exist within the MANUFACTURING sector. Our model identifies several "Strong Buy" candidates with higher quality scores and more attractive valuations among direct industry competitors.
View Top Manufacturing Alpha →Quant Factor Profile
Key factor gap
Value (91) vs Investment (25) — closing this gap could shift the rating.
EV/EBITDA 30% BELOW SECTOR MEDIAN (FAVORABLE)
ROE 980% BELOW SECTOR MEDIAN
Gross Margin 86% ABOVE SECTOR MEDIAN (FAVORABLE)
AUDIT DATA AS OF SEP 30, 2025 (Q2 FY2025)
We rate Harmony Biosciences Holdings, Inc. (HRMY) as a Hold with a composite score of 55.3/100 at a current price of $28.20. The stock presents a mixed quantitative picture — neither compelling enough to warrant new accumulation nor weak enough to justify selling for existing holders. Our factors are split, and the overall profile suggests patience is warranted.
The rating is primarily driven by strength in value (91th percentile) and quality (81th percentile), which together account for the majority of the composite score. Offsetting weakness in investment (25th percentile) and momentum (33th percentile) tempers our overall conviction. We assign a Wide Moat rating (76/100), Low uncertainty, and Exemplary capital allocation.
Key items to watch: momentum to confirm whether the current price trend has legs; sustainability of the current growth rate. Any material change in these dynamics could warrant a reassessment of our rating. The moat trend is stable, which suggests the competitive landscape is stable for now.
Harmony Biosciences Holdings, Inc. holds a top-quartile position (#0 of 50) within the Manufacturing sector, based on our composite quantitative scoring across quality, value, momentum, and stability factors. The composite score of 55.3/100 places it at rank #1228 in our full 7,333-stock universe. At $1.6B in market capitalization, Harmony Biosciences Holdings, Inc. is a small-cap player in the Manufacturing space, which limits certain scale advantages but may allow for more agile strategic execution.
Revenue is growing at 39%, though momentum at the 33th percentile suggests the market has not yet fully recognized this trajectory. This potential disconnect between fundamental improvement and market recognition could represent an opportunity for patient investors if the growth trend persists.
The margin cascade tells an important story: gross margins of 79% (+36.4pp vs sector) narrow to operating margins of 29% (+27.5pp vs sector) and net margins of 22.6%, yielding a gross-to-net conversion rate of 29%. This conversion rate is typical for the sector, suggesting a standard cost structure without notable efficiency advantages or disadvantages.
At a current price of $28.20, Harmony Biosciences Holdings, Inc. appears undervalued relative to its fundamentals. Our value factor score of 91/100 reflects a composite assessment across multiple valuation metrics including price-to-earnings, price-to-book, EV/EBITDA, and price-to-sales ratios relative to both sector peers and the broader market. The stock screens as attractively priced on a majority of these measures, suggesting the market may be underappreciating the underlying fundamentals.
The stock currently trades at a P/E of 9.2x (a 59% discount to the sector median of 22.3x), EV/EBITDA of 8.0x (discounted to peers), P/B of 2.0x, P/S of 2.1x. The below-sector P/E suggests possible undervaluation or the market pricing in near-term headwinds.
Gross margins of 79% signal strong pricing power and brand/IP advantages — businesses with margins above 40% have historically demonstrated more resilient earnings through economic cycles.
Returns on equity of 21.8% exceed the cost of equity for most companies, indicating genuine shareholder value creation and a reinvestment engine that compounds wealth over time.
Revenue growth of 39% confirms the business is expanding its addressable market — growth at this level typically supports multiple expansion and attracts institutional capital.
A value factor score of 91/100 suggests the market is underpricing these fundamentals, creating a potential margin of safety for new investors.
A conservative balance sheet (20% D/E) provides financial flexibility for acquisitions, buybacks, or weathering economic downturns without dilution.
We assign a Low uncertainty rating to Harmony Biosciences Holdings, Inc.. The company exhibits strong financial stability with a beta of 0.55, conservative leverage (20% D/E), and a stability factor in the 68th percentile. The predictable nature of the business model and solid financial position reduce the range of potential outcomes, giving us confidence in our fair value estimate.
Specific risk factors that inform our assessment include: low beta of 0.55 — while defensive, this may indicate limited upside participation in bull markets. Each of these factors independently widens the distribution of potential outcomes, and in combination they create a risk profile that demands careful position sizing. The stability factor at the 68th percentile and quality factor at the 81th percentile provide a quantitative summary of the overall risk landscape.
Key risk mitigants include: healthy gross margins of 79% provide a buffer against cost pressures; conservative leverage (20% D/E) limits balance sheet risk; above-average stability (68th percentile) suggests predictable business dynamics. These factors partially offset the identified risks and provide downside protection in adverse scenarios. On balance, the risk-reward profile is favorable for long-term investors.
We rate Harmony Biosciences Holdings, Inc.'s capital allocation as Exemplary. Management demonstrates a strong track record of balancing reinvestment with shareholder returns, evidenced by returns on equity of 21.8%, disciplined leverage (20% D/E), best-in-class net margins of 22.6%. Exemplary allocators typically generate returns on equity above 20% while maintaining debt-to-equity below 50% — Harmony Biosciences Holdings, Inc. meets this high bar.
The balance sheet remains conservatively managed, providing financial flexibility for opportunistic investments while maintaining a margin of safety for shareholders. We note that the combination of 15.1% return on assets and controlled leverage suggests management is deploying capital at rates well above the cost of capital — the hallmark of exemplary stewardship.
In summary, Harmony Biosciences Holdings, Inc. receives a Hold rating with a composite score of 55.3/100 (rank #1228 of 7,333). Our quantitative framework assigns a Wide Moat (76/100, trend: stable), Low uncertainty, and Exemplary capital allocation. The average factor score across quality, value, momentum, stability, and investment is 60/100.
Our analysis supports a neutral stance on Harmony Biosciences Holdings, Inc.. While the quantitative profile is not weak enough to warrant selling, it lacks the multi-factor strength required for a buy recommendation. Existing holders should maintain positions and monitor for catalysts — either fundamental improvement or valuation compression — that would shift the risk-reward balance.
Analysis derived from Blank Capital Research quantitative terminal. For informational purposes only. No trade solicitation. Past performance not indicative of future results. Consult a qualified advisor.
We assign Harmony Biosciences Holdings, Inc. a Wide Moat rating with a composite moat score of 76/100. This places the company among an elite group of businesses with deep, durable competitive advantages that we expect to persist for 20 years or more. The score reflects strength across multiple competitive dimensions, with margin superiority (19.4/20) as the leading contributor.
The strongest moat sources are margin superiority (19.4/20) and growth durability (18.8/20). GM 79% vs sector 43%, OM 29% vs sector 1%. Rev growth 39%, 6yr history. These pillars form the core of Harmony Biosciences Holdings, Inc.'s competitive identity and are the primary drivers of excess returns in our framework.
Areas of relative weakness include reinvestment efficiency (7/20) and economic value creation (13.2/20). Capital turnover N/A, R&D intensity 22.4%. Improvement in these areas could meaningfully widen the moat over time, while deterioration would be an early warning of competitive erosion.
Our moat trend assessment is Stable. Multi-year ROIC and operating margin trajectories show neither meaningful improvement nor deterioration, suggesting the competitive position is steady. We expect Harmony Biosciences Holdings, Inc.'s moat profile to remain largely unchanged absent a material shift in return on capital or industry dynamics.
Key profit drivers include gross margins of 79% providing a solid profitability foundation, operating margins of 29% reflecting effective cost management, robust top-line growth of 39% expanding the revenue base. The margin cascade from 79% gross to 29% operating to 22.6% net reveals the company's cost structure and reinvestment intensity. Our analysis indicates that the profit engine is high-quality and likely sustainable, with the quality factor at the 81th percentile.
The margin profile shows gross margins of 79%, operating margins of 29%, net margins of 22.6%. Return metrics include ROE of 21.8% and ROA of 15.1%. Relative to the Manufacturing sector, gross margins are 36.4 percentage points above the sector median of 43%, and ROE of 21.8% compares to a sector median of -2.5%.
The balance sheet reflects a conservatively managed balance sheet with D/E of 20%, revenue growth of 39%. The sector median D/E is 0%, putting Harmony Biosciences Holdings, Inc. at higher leverage than the typical peer. The combination of low leverage and healthy profitability provides significant financial resilience and strategic optionality.
Weak momentum (33th percentile) suggests institutional selling pressure and unfavorable technical dynamics that may persist.
Deutsche Bank has downgraded Harmony Biosciences (NASDAQ:HRMY) to Hold from Buy and lowered its price target due to increased patent risk for its lead drug Wakix. This follows a bench trial where a judge reportedly leaned negatively towards Harmony Biosciences regarding intellectual property challenges from AET Pharma, potentially accelerating Wakix's loss of exclusivity. Despite the legal uncertainty, the company recently reported strong preliminary net product revenue for Wakix and announced partnerships for new studies, with other analysts maintaining positive ratings based on promising trial data for other drug candidates.

The Public Sector Pension Investment Board increased its stake in Harmony Biosciences Holdings, Inc. (NASDAQ:HRMY) by 41.6% during the third quarter, purchasing an additional 54,605 shares and bringing its total holdings to 185,803 shares valued at $5.12 million. Other institutional investors have also adjusted their positions in the company, which currently has a market capitalization of $1.98 billion and an average analyst rating of "Moderate Buy." Insider trading activity included sales by the CEO and CFO totaling over $1.1 million in the last quarter.
Harmony Biosciences Holdings (HRMY), a biotechnology company specializing in rare neurological diseases, shows significant investment potential with a 29.76% estimated upside. Its current valuation, robust revenue growth of 28.70%, strong EPS, and substantial free cash flow highlight its financial strength. The company's diverse product pipeline and positive analyst ratings further underscore its promising future in the healthcare sector.

Universal Beteiligungs und Servicegesellschaft mbH increased its stake in Harmony Biosciences (NASDAQ:HRMY) by 39.3% in the third quarter, now owning 234,779 shares valued at $6.47 million. Other institutional investors like Robeco Institutional Asset Management and Capital Fund Management also acquired new stakes, while Nomura Holdings Inc. and Arrowstreet Capital Limited Partnership significantly boosted their holdings. Harmony Biosciences reported Q3 EPS of $0.87, missing analyst estimates but exceeding revenue expectations, and multiple analysts have recently updated their ratings to "Buy" or "Outperform."

Zacks Research upgraded Harmony Biosciences (NASDAQ:HRMY) from a "hold" to a "strong-buy" rating. The company's stock currently holds an average "Buy" rating from analysts, with a consensus price target of $45.25. Despite recent insider selling by the CFO and CEO, institutional investors show increased interest, and the company has demonstrated strong revenue in its last quarter, although EPS slightly missed expectations.
Above 50MA
37.18%
Net New Highs
+51081