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Verdict
Quantitative factor alignment verified for current market regime.
Quant Score
Rank
#4019
Positioning
Market Dominance
Manufacturing
Pharmaceutical Products
$364M
Theis Terwey
GH Research PLC was incorporated in 2018 and is based in Dublin, Ireland. The company focuses on developing 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) therapies for the treatment of patients with treatment-resistant depression (TRD)
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| Stock | Rating | Score▼ | Quality | Value | Momentum | P/E | EV/EBITDA | ROE | ROA | Gross Mgn | Op Mgn | Net Mgn | Rev Growth | Div Yield | D/E | Mkt Cap | AUDIT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
$UL UNILEVER PLC | 78 | 96 | 98 | 59 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$ASML ASML HOLDING NV | 77 | 89 | 86 | 83 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$ESLT ELBIT SYSTEMS LTD | 76 | 81 | 87 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$MT ArcelorMittal | 75 | 71 | 98 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$AMAT APPLIED MATERIALS INC /DE | 75 | 85 | 87 | 84 | 20.9x | 13.6x | 32.9% | 20.5% | 48.8% | 30.6% | 24.4% | 7.7% | 0.9% | 32.0x | $148.6B | VS | |
$SIMO Silicon Motion Technology CORP | 75 | 84 | 86 | 85 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$CODA Coda Octopus Group, Inc. | 74 | 83 | 90 | 79 | 16.3x | 11.9x | 7.4% | 7.5% | 68.3% | 19.5% | 18.2% | 29.0% | 0.0% | 0.0x | $84M | VS | |
$GSK GSK plc | 74 | 84 | 90 | 70 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$EFXT Enerflex Ltd. | 74 | 80 | 91 | 83 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$BUD Anheuser-Busch InBev SA/NV | 74 | 84 | 97 | 63 | - | - | - | - | - | - | - | - | - | - | $0 | VS | |
$GHRS GH Research PLC | 36 | 21 | 19 | 57 | - | - | -87.1% | -82.8% | - | - | - | - | 0.0% | 0.0x | $364M | ||
| SECTOR BENCH | - | - | - | - | - | 22.3x | 11.5x | -1.9% | 0.9% | 44.1% | 2.5% | 1.0% | 6.7% | 0.0% | 0.2x | - | REF |
GH Research PLC (GHRS) receives a "Avoid" rating with a composite score of 35.9/100. It ranks #4019 out of 7,333 stocks in our coverage universe and carries a 1-star rating. Ratings are driven by a 6-factor quantitative model measuring quality, value, momentum, investment, stability, and short interest.
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In-line with peers — no strong momentum signal
Expensive relative to fundamentals — limited margin of safety
Weak fundamentals — higher risk of value trap
Average volatility — neutral timing signal
Aggressive spending — empire-building risk, dilutive growth
Below-average composite — caution warranted
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Relative valuation derived from Manufacturing sector benchmarks. Model weights: EV/EBITDA (40%), P/B (35%), P/S (25%). Re-calculated daily.
No analyst ratings for GHRS.
View All RatingsROE proxy -87.1% (sector -1.9%)
GM N/A vs sector 44%, OM N/A vs sector 3%
Capital turnover N/A
Rev growth N/A, 4yr history
Interest coverage -70.2x
Composite assessment of profitability, capital efficiency, and financial strength. Top-tier entities demonstrate sustainable cash flow generation and elite competitive moats.
Profit generated per dollar of shareholder equity
Efficiency of asset utilization
Pricing power and cost efficiency
Core business profitability
Bottom-line profitability
The Quality factor evaluates the persistence and magnitude of realized cash flows. Companies with scores >70 exhibit superior pricing power and structural financial resilience through diverse economic regimes.
Our uncertainty rating tracks the predictability of future cash flows and potential for permanent capital loss. Moderate visibility with standard industry cyclicality.
We rate GH Research PLC (GHRS) as Avoid with a composite score of 35.9/100 at a current price of $15.27. The stock falls in the bottom quintile, and the multi-factor weakness suggests a high probability of continued underperformance.
GH Research PLC holds a top-quartile position (#0 of 50) within the Manufacturing sector, based on our composite quantitative scoring across quality, value, momentum, and stability factors. The composite score of 35.9/100 places it at rank #4019 in our full universe.
No Moat
Medium
Poor
Fair Value
Stable competitive position in a defensive sector.
Below-average quality raises earnings sustainability concerns.
Vulnerability to macroeconomic shocks and interest rate volatility.
GH Research PLC represents a avoid based on multi-factor quantitative performance.
Our quantitative model flags GH Research PLC with an Avoid rating, assigning a composite score of 35.9/100 and 1 out of 5 stars. Ranked #4019 of 7,333 stocks, GHRS falls in the bottom tier across key factors. Historically, stocks with this profile have faced elevated risk of underperformance and capital loss.
GH Research PLC registers a weak quality score of just 21/100, indicating significant profitability challenges. The company reports a return on equity of -87.1% (sector avg: -1.9%). Low quality scores are often associated with businesses in turnaround mode, early-stage growth, or structurally challenged industries.
GHRS registers a value score of just 19/100, suggesting the stock trades at a significant premium to its fundamental metrics. Key valuation metrics include a P/B ratio of 5.41x. High-premium valuations like this require strong future execution to avoid multiple compression, and downside risk is elevated if growth disappoints.
GH Research PLC's investment score of 29/100 suggests limited reinvestment activity. Key growth metrics include a return on assets of -82.8% (sector: 0.9%). While this can be positive for mature, cash-generative businesses returning capital to shareholders, it may also signal a lack of growth opportunities or management conservatism.
GHRS demonstrates moderate momentum with a score of 57/100, suggesting a neutral price trend without strong directional conviction. Revenue growth data is not currently available, while a beta of 1.08 reflects its sensitivity to broader market moves. Moderate momentum may indicate the stock is consolidating or transitioning between trends, warranting close monitoring of upcoming catalysts.
With a stability score of 48/100, GHRS exhibits average financial resilience. Key stability metrics include a beta of 1.08 and a debt-to-equity ratio of 0.00x (sector avg: 0.2x). While the balance sheet is not a major concern, the stock is subject to typical market volatility and may experience sharper drawdowns during risk-off episodes.
GH Research PLC's short interest score of 10/100 reveals significant bearish positioning, suggesting institutional investors are actively betting against the stock. Specific risk factors include small-cap liquidity risk. At $364M (small-cap), GHRS carries meaningful risk and is best suited for investors with high risk tolerance who have thoroughly evaluated the bear thesis.
GH Research PLC is a small-cap company in the Manufacturing sector, ranked #0 of 50 in its sector (100th percentile) and #4019 of 7,333 overall (45th percentile). Key comparisons include ROE of -87.1% trailing the -1.9% sector median. This top-quartile standing reflects exceptional competitive strength relative to Manufacturing peers.
While GHRS currently exhibits a AVOID profile, superior opportunities exist within the MANUFACTURING sector. Our model identifies several "Strong Buy" candidates with higher quality scores and more attractive valuations among direct industry competitors.
View Top Manufacturing Alpha →Quant Factor Profile
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Improvement in Short Int. (10) would have the largest impact on the composite score.
ROE 4484% ABOVE SECTOR MEDIAN (FAVORABLE)
Debt/Equity 100% BELOW SECTOR MEDIAN (FAVORABLE)
Div. Yield NaN% BELOW SECTOR MEDIAN
Above 50MA
37.18%
Net New Highs
+51081
GH Research PLC (NASDAQ:GHRS) is among the 7 Most Promising Psychedelic Stocks According to Hedge Funds. GH Research PLC (NASDAQ:GHRS) is placed sixth on our list. TheFly reported that on January 23, RBC Capital raised its price target on GHRS to $40 from $33 and maintained an Outperform rating. RBC stated that it was growing […]
GH Research (NasdaqGM:GHRS) is back in focus after the U.S. Food and Drug Administration lifted the clinical hold on its GH001 IND, clearing the way for U.S. enrollment in treatment-resistant depression trials. See our latest analysis for GH Research. The FDA decision appears to have been a key catalyst, with a 1 day share price return of 27.12% and a 7 day share price return of 41.34% lifting the stock to $17.95. At the same time, the 1 year total shareholder return of 99.89% and 3 year...

U.S. stock futures rose on Monday as major indices opened the first full trading week of 2026 higher. Following the U.S. strike on Venezuela and removal of President Maduro, crude oil prices fluctuated around $57.29 per barrel. Several stocks gained attention: Vertiv Holdings jumped on an upgrade, GH Research soared on FDA update news, Nukkleus rose after acquiring Israeli defense software, Ironwood advanced on positive FY26 guidance, and Brand Engagement Network climbed on a new vendor agreement. JPMorgan's outlook suggests continued but challenged strength in U.S. equities, with potential 10-15% corrections offset by year-end gains driven by AI-related spending.
Shares of at least four other developers were up by mid-single digits to low-double digits at certain points on Tuesday.
GH Research PLC recently reported that the U.S. Food and Drug Administration lifted the clinical hold on its GH001 investigational new drug application, allowing U.S. subject enrollment following Phase 2b data in treatment-resistant depression showing a 15.5-point placebo-adjusted MADRS score reduction by Day 8, high remission rates with infrequent dosing, brief psychoactive sessions, and no serious treatment-related adverse events. This combination of rapid symptom relief, minimal treatment...